Year: 2013 | Month: June | volume 6 | Issue 2
In-silico Interaction Studies of Alternaria brassicae Toxin Destruxin B and Potential Partners of MAPK4 Cascade
Abstract: Alternaria blight is one of the important fungal diseases of Brassica plant which leads to major yield losses as well as deterioration in quality. Plant responds toward fungal attack through intricate signal transduction pathways involving MAPKs. In the present study an effort was taken to delineate the MAP kinase pathway involving MAPK4 through in-silico interaction studies. Here we have reported that destruxin B has strong interaction with Lys M receptor kinase and Lys M receptor and toxin interaction was differential with different host. Lys M receptor kinase showed strong interaction with MAPKKK19. Out of ten MAPKKs known four MAPKK viz. MAPKK3, MAPKK5, MAPKK8 and MAPKK9 showed good interaction with MAPK4. Among these four interacting MAPKKs, MAPKK9 showed best interaction with MAPKKK19. At the downstream of the cascade MAPK4 showed strong interaction with WRKY 25 and WRKY 40.The results of the present study clearly indicate the role of MAPK4 in plant defense against Alternaria blight.
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